Maximizing Production Throughput – Customer Story

By Dassault Systèmes

Pacira is an emerging specialty pharmaceutical company headquartered in the US that focuses on the clinical and commercial development of new products that meet the needs of acute care practitioners and their patients. The company’s emphasis is the development of non-opioid products for post-surgical pain control.

Pacira has developed a proprietary product delivery technology (DepoFoam®) that encapsulates drugs without altering their molecular structure and then releases them over a desired period of time. This improves products’ efficacy and safety, making a critical difference to patients in terms of dosing frequency and administration.

The product EXPAREL® based on this technology is marketed to replace opioids for post-surgical treatments eliminating addiction and overdose deaths. It is manufactured in San Diego, US and Swindon, UK. The production of the emulsion is very difficult to control, involving two emulsion steps: solvent stripping and buffer addition for storage and potency adjustment.

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