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Dassault Systèmes solutions create an unmatched scientific management environment that can help science-based organizations create and connect biological, chemical and material innovations to improve the way we live.
A leading Pharmaceutical Manufacturer leverages DELMIA Ortems software to plan, schedule and optimize operations at more than 18 facilities around the world, integrated with a variety of ERP environments.
Recognized as a world leader in the pharmaceutical industry as well as in human vaccines, the manufacturer offers an extensive portfolio of pharmaceutical products, including prescription drugs, generics, consumer healthcare and animal health products. It needed to find a better method to manage production in a highly complex manufacturing environment, which includes varied manufacturing modes such as the manufacturing of pills, coated tablets, gels, eye drops, injectables and other products.
In order to make up for its ERP's functional shortcomings in finite-capacity planning and scheduling, the manufacturer initiated a process to optimize its manufacturing processes so it can transition from a static to a dynamic planning and scheduling mode with DELMIA Ortems.
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Pacira is an emerging specialty pharmaceutical company headquartered in the US that focuses on the clinical and commercial development of new products that meet the needs of acute care practitioners and their patients. The company’s emphasis is the development of non-opioid products for post-surgical pain control.
Pacira has developed a proprietary product delivery technology (DepoFoam®) that encapsulates drugs without altering their molecular structure and then releases them over a desired period of time. This improves products’ efficacy and safety, making a critical difference to patients in terms of dosing frequency and administration.
The product EXPAREL® based on this technology is marketed to replace opioids for post-surgical treatments eliminating addiction and overdose deaths. It is manufactured in San Diego, US and Swindon, UK. The production of the emulsion is very difficult to control, involving two emulsion steps: solvent stripping and buffer addition for storage and potency adjustment.
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The growing global demand for pharmaceuticals due to longer, more affluent living, presents many challenges for the industry. While the Life Sciences and Healthcare industry aims to improve the quality of our longer lives, there is a growing recognition that the pharmaceutical sector must do more to improve its sustainability performance.
To meet the high demands of sustainability, traditional ways of innovating will not affect manufacturing sustainability quickly or effectively enough. Instead, manufacturers need to leverage the power of the virtual twin to optimize their real-world impact before building their plants and supply network.
Virtual twins are a crucial solution to solve complex pharmaceutical manufacturing sustainability challenges, such as achieving zero carbon and integrating more closely with the circular economy.
This white paper explains relevant aspects of the Digital Lab - an overall laboratory informatics solution that spans the lab-to-commercialization product lifecycle, using data standardization/ harmonization technology and integrated platform capabilities to streamline technology transfer and support operational excellence initiatives.
The paper also addresses the usefulness of a single, unified, scientifically aware environment in accomplishing technology handoffs along the lab-to-plant continuum, and the importance of consistent, standard procedures for managing data and processes from lab to commercialization.
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The BIOVIA Unified Lab offers research, development, analytical and QA/QC laboratories a unique opportunity to truly digitalize their lab processes and to connect analytical and process workflows end-to-end. With the Unified Lab from BIOVIA, daily workflows are truly digitalized, non-value added tasks are minimized and organization are able to transform their lab operations.
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The right electronic lab notebooks (ELNs) strategy and solution can set your organization above the competition in terms of scientific information capture, workflow optimization, process consistency, IP protection, collaboration within global virtual teams and improved productivity through knowledge sharing.
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Life Sciences organizations need to bring new high-quality therapeutics to market fast to respond to patient needs specific to different diseases and geographies. But development time and costs for new therapeutics are gigantic with an average accrual of $2.6B and 12 years from ideation to market. Reasons for the struggle include (1) the long “time to fail” in new target identification, (2) increasing global and regional regulations and
scrutiny, and (3) the major efforts required to ensure that therapeutics are safe, efficacious and compliant with specifications. Personalized Medicine and Patient Centricity add complexity to Development and Manufacturing. Testing is required to confirm therapeutic characteristics discovered during Research, to identify and optimize formulations for production and scale-up, and to release active ingredients and products.
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To accelerate digital transformation, companies are opting for a cloud-based implementation of the Dassault Systèmes 3DEXPERIENCE platform. The first stage is leveraging BIOVIA Scientific Notebook on the 3DEXPERIENCE platform. Experimental data from legacy electronic lab notebooks (ELNs) can be indexed and accessed with Scientific Notebook, making it into a single, centralized database on the platform for all researchers and scientists.
Download this use case to see how BIOVIA Scientific Notebook and the 3DEXPERIENCE platform are helping life sciences companies continue their digital transformation journeys.
This medical device company develops, manufactures and markets critical customer care products worldwide. To improve the efficiency of company offices, manufacturing facilities and distribution centers around the world, the company approached Dassault Systèmes to assist them in better integrating the common elements of compliance including content, processes, people and systems across the organization.
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Life Science companies face major challenges to continued operations and profitability from patent expirations, low R&D productivity, increased competition, decreased margins, inefficient processes, and mounting compliance constraints.
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