Referring to a method of computationally intensive science, e-Science is carried out in highly distributed network environments.

This can also be used to describe science that is using large sized data sets that require grid computing.

It is most commonly thought of as the application of computer technology to aide modern scientific investigation. This includes the preparation, experimentation, data collection, results, dissemination, and long-term storage and accessibility of all materials generated through the scientific process.

Some of the processes undertaken may include things like data modelling and analysis.

Due to the vast amounts of data being dealt with, e-Science typically relies upon a large team. For example the CERN Large Hadron Collider produces huge amounts of data and has led to the development of e-Science and Grid infrastructures which are now also used by other disciplines.

Several centres in the UK support e-Science with projects in universities. These centres include Cambridge e-Science Centre, Centre for eResearch Bristol, and National Grid Service.